师资队伍

  • 姓名:李睿
  • 职称:教授
  • 研究领域:室内甲醛污染对人体健康的影响;环境邻苯二甲酸酯对人体健康的影响;纳米材料对生物分子的作用与纳米材料的健康效应;环境分子毒理学
  • 联系方式:ruili(AT)mail.ccnu. edu.cn
  • 办公室地址:5319室
  • 更多信息:

教育经历:

  20117-20126月:美国西弗吉尼亚大学  博士后

  20057-201010月:新加坡南洋理工大学  生物工程博士学位

      19979-20006月:华中师范大学  植物学硕士学位

      19929-19966月:华中师范大学  生物学硕士学位

 

工作经历:

      20007月至今 :华中师范大学生命科学学院  助教、讲师、副教授教授

      20171-20174美国加利福尼亚大学伯克利分校  访问学者

 

荣誉或奖励:

  201711月:完成的项目微纳米尺度粒子毒理学效应的基础研究与应用获得中华预防医学会科学技术奖二等奖(排名第三)

  20175月:主讲分子生物学(英语)课程获华中师范大学第三届本科生教学创新奖一等奖第一名

  20176月:主持教研项目信息化环境下的英语《分子生物学》教学研究获结项优秀

  201710月:指导研究生获中国环境科学学会学术年会优秀论文二等奖

  201711月:指导研究生获中国环境科学学会室内环境与健康分会学术年会优秀论文奖

  2016年主讲分子生物学(英语)课程获校第五批数字化资源认证B类课

  201412月:获华中师范大学年度教学工作优秀二等奖

  201310月:主讲生物化学获教育部举办首届全国高校微课教学比赛中获得优秀奖暨湖北省一等奖

  20145月:指导本科生完成科研论文并获湖北省大学生优秀科研成果二等奖

  2012年、2014年两次获校优秀实习指导教师称号

 

主要研究领域:

环境分子毒理学相关研究

- 室内甲醛污染对人体健康的影响

- PM2.5污染对人体健康的影响

- 环境邻苯二甲酸酯对人体健康的影响

- 纳米材料对生物分子的作用与纳米材料的健康效应

 

承担科研项目:

1. 科技部“十三五”重点研发计划项目(2017YFC0702701):建筑室内主要空气污染物清单及其健康影响机理研究(子课题),2017.07-2020.06,主持(80万元)

2. 中央高校基本科研业务费重大项目:环境毒理系统生物学研究,2018.06-2020.05,主持60万元

3. 国家自然科学基金青年基金项目(21103059):形貌效应对纳米氧化钨-菌紫质复合体光电响应的影响与调控机制,2012.01-2014.12,主持(26万元)

4. 国家自然科学基金面上项目(21577045):PM2.5和甲醛复合暴露致小鼠哮喘样病变分子机制的研究,2016.01-2019.12骨干83万元)

5. 国家自然科学基金重点项目(51136002):室内半挥发性有机物污染控制中的关键工程热物理问题研究,2012.01-2016.12骨干80万元)

6. 教育部直属高校聘请外国文教专家计划-学校特色项目(TS2012HZSF042):环境健康学科平台建设,2012.01-2015.12骨干60万元)

7. 中央高校基本科研业务费项目(CCNU15A02028):不同维度对于纳米氧化钨致小鼠神经毒性的影响研究2015.01-2016.12,主持

8. 中央高校基本科研业务费项目(CCNU12A01006):形貌效应对纳米氧化钨-菌紫质复合体光电响应的影响与调控机制2012.01-2013.12,主持

 

代表性论文:

1. Xu Zhang, Yun Zhao, Jing Song, Xu Yang, Junfeng Zhang, Yinpin Zhang*, Rui Li*. 2018. Differential health effects of constant versus intermittent exposure to formaldehyde in mice: implications for building ventilation strategies. Environmental Science & Technology, 52: 1551-1560.

2. Qing Guo, Huihui You, Xu Yang, Bencheng Lin, Zhihong Zhu, Zhisong Lu, Xiaoxiao Li, Yun Zhao, Lin Mao, Shiping Shen, Haoyan Cheng, Jiting Zhang, Lingfu Deng, Jianhua Fan, Zhuge Xi*, Rui Li*, Chang Ming Li. 2017. Functional single-walled carbon nanotubes 'CAR' for targeting dopamine delivery into the brain of parkinsonian mice. Nanoscale, 9(30):10832-10845.

3. Meng Qi, Jiawei Huang, Hui Wei, Chaomin Cao, Shilun Feng, Qing Guo, Ewa M. Goldys, Rui Li, and Guozhen Liu*. 2017. Graphene Oxide Thin Film with Dual Function Integrated into a Nanosandwich Device for in Vivo Monitoring of Interleukin-6, ACS Applied Materials and Interfaces, 9: 41659-41668.

4. Jing Song, Jun Kang, Bencheng Lin, Jinquan Li, Yuqing Zhu, Junting Du, Xu Yang, Zhuge Xi, Rui Li*. Mediating role of TRPV1 ion channels in the co-exposure to PM2.5 and formaldehyde of Balb/c mice asthma model. Scientific Reports, 7:11926.

5. Rui Li, Chang Ming Li*, Haifeng Bao, Qiaoliang Bao, and Vee S. Lee. 2007. Stationary current generated from photocycle of a hybrid bacteriorhodopsin/quantum dot bionanosystem. Applied Physics Letters, 91: 223901.

6. Rui Li, Fengping Hu, Qiaoliang Bao, Shujuan Bao, Yan Qiao, Shucong Yu, Jun Guo, Chang Ming Li*. 2010. Enhancement of photoelectric response of bacteriorhodopsin by multilayered WO3•H2O nanocrystals/PVA membrane. Chemical Communications, 46: 689-691.

7. Rui Li, Xiaoqiang Cui, Weihua Hu, Zhisong Lu, Chang Ming Li*. 2010. Fabrication of Oriented Poly-L-lysine/Bacteriorhodopsin-embedded Purple Membrane Multilayer Structure for Enhanced Photoelectric Response. Journal of Colloid and Interface Science, 344: 150-157.  

8. Rui Li, Ye Gan, Qunliang Song, Zhihong Zhu, Jingsheng Shi, Hongbing Yang, Wei Wang, Peng Chen, Chang Ming Li*. 2010. Bidirectional Mediation of TiO2 Nanowires Field Effect Transistor by Dipole Moment from Purple Membrane. Nanoscale. 2: 1474-1479.

9. Na Ren,# Rui Li,# Limei Chen, Guancong Wang, Duo Liu, Yingjun Wang, Lin Zheng, Wei Tang, Xiaoqiang Yu, Huaidong Jiang, Hong Liu*, Nianqiang Wu. 2012. In situ construction of a titanate-silver nanoparticle-titanate sandwich nanostructure on a metallic titanium surface for bacteriostatic and biocompatible implants. Journal of Materials Chemistry, 22: 19151-19160.

10. Zhisong Lu*, Jing Wang, Xiutao Xiang, Rui Li, Yan Qiao, Chang Ming Li*. 2015. Integration of bacteriorhodopsin with upconversion nanoparticles for NIR-triggered photoelectrical response, Chemical Communications, 51: 6373-6376.

11. Zhisong Lu,* Jing Wang, Rui Li, Yan Qiao, Mengyao Zhou and Chang Ming Li*. 2016. Controllable stationary photocurrents generated from a bacteriorhodopsin/upconversion nanoparticle-based bionanosystem under NIR illumination. Nanoscale, 8:18524.

12. Huihui You#, Rui Li #, Chenxi Wei, Shaohui Chen, Lin Mao, Zhenye Zhang, Xu Yang*. 2016. Thymic Stromal Lymphopoietin Neutralization Inhibits the Immune Adjuvant Effect of Di-(2-Ethylhexyl) Phthalate in Balb/c Mouse Asthma Model. PLoS One, 11:e0159479.

13. Shuai Shang, Jinquan Li, Yun Zhao, Zhuge Xi, Zhisong Lu, Baizhan Li, Xu Yang*, Rui Li*. 2017. Oxidized graphene-aggravated allergic asthma is antagonized by antioxidant vitamin E in Balb/c mice. Environmental Science and Pollution Research, 24:1784-1793.

14. Xudong Liu, Qing Guo, Yuchao Zhang, Jinquan Li, Rui Li, Yang Wu, Ping Ma, and Xu Yang*. 2016. Intraperitoneal injection is not a suitable administration route for single-walled carbon nanotubes in biomedical applications. Dose-Response: An International Journal, 14:1-7.

15. Yuqing Zhu, Jinquan Li, Zhuo Wu, Yu Lu, Huihui You, Rui Li, Baizhan Li, Xu Yang* and Liju Duan*. 2016. Acute exposure of ozone induced pulmonary injury and the protective role of vitamin E through the Nrf2 pathway in Balb/c mice. Toxicology Research, 5:268-277.

16. Haoyan Cheng, Lin Mao, Lele Wang, Hao Hu, Yangyang Chen, Zheni Gong, Chengjun Wang, Jisheng Chen, Rui Li*, Zhihong Zhu*. 2015. Bidirectional regulation of zinc embedded titania nanorods: antibiosis and osteoblastic cell growth. RSC Advances, 5: 14470-14481.

17. Haoyan Cheng, Lin Mao, Xing Xu, Yan Zeng, Danni Lan, Hao Hu, Xu Wu, Huihui You, Xu Yang, Rui Li*, Zhihong Zhu*. 2015. The bifunctional regulation of interconnected Zn-incorporated ZrO2 nanoarrays in antibiosis and osteogenesis. Biomaterials Science, 3: 665-680.

18. Xudong Liu, Yuchao Zhang, Jinquan Li, Dong Wang, Yang Wu, Yan Li, Zhisong Lu, Samuel C. T. Yu, Rui Li*, Xu Yang*. 2014. Cognitive deficits and decreased locomotor activity induced by single-walled carbon nanotubes and neuroprotective effects of ascorbic acid. International Journal of Nanomedicine, 9: 823-839.

19. Huihui You, Shaohui Chen, Lin Mao, Bing Li, Ye Yuan, Rui Li*, Xu Yang*. 2014. The adjuvant effect induced by di-(2-ethylhexyl) phthalate (DEHP) is mediated through oxidative stress in a mouse model of asthma, Food and Chemical Toxicology, 71: 272-281.

20. Chenjuan Ke, Yahui He, Hongwu He, Xu Yang, Rui Li*, Junlin Yuan*. 2014. A new spectrophotometric assay for measuring pyruvate dehydrogenase complex activity: a comparative evaluation, Analytical Methods, 6(16): 6381-6388.

21. Jinquan Li, Li Li, Hanqing Chen, Qing Chang, Xudong Liu, Yang Wu, Chenxi Wei, Rui Li, Joseph K. C. Kwan, King Lun Yeung, Zhuge Xi, Zhisong Lu, Xu Yang*. 2014. Application of vitamin E to antagonize SWCNTs-induced exacerbation of allergic asthma, Scientific Reports, 4: 4275.

22. Jinquan Li, Li Li, Xudong Liu, Rui Li, Xu Yang*. 2013. Single-wall carbon nanotube-induced airway hyperresponsiveness in rats and a postulated mechanism of action, RSC Advances, 3(47): 25388-25395.

23. Yuchao Zhang, Xudong Liu, Cliona McHale, Rui Li, Luoping Zhang, Yang Wu, Xin Ye, Xu Yang, Shumao Ding*. 2013. Bone Marrow Injury Induced via Oxidative Stress in Mice by Inhalation Exposure to Formaldehyde, PLos One, 8(9): e74974.

24. Shiping Shen, Jinquan Li, Huihui You, Zhuo Wu, Yang Wu, Yun Zhao, Yuqing Zhu, Qing Guo, Xiaoxiao Li, Rui Li, Ping Ma, Xu Yang*, Mingqing Chen*. 2017. Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin, Food and Chemical Toxicology, 99: 60-69.

25. Yujie Ke, Xiaodan Qin, Yuchao Zhang, Hui Li, Rui Li, Junlin Yuan, Xu Yang, Shumao Ding*. 2014.  In vitro study on cytotoxicity and intracellular formaldehyde concentration changes after exposure to formaldehyde and its derivatives, Human & Experimental Toxicology, 33(8): 822-830.

26. Hongbo Xu, Ranfeng Ye, Shangyue Yang, Rui Li, Xu Yang*. 2014. Electrochemical DNA nano-biosensor for the detection of genotoxins in water samples, Chinese Chemical Letters, 25(1): 29-34.

27. Xiaoxiao Chen, Xing Zhu, Rui Li, Hanchao Yao, Zhisong Lu, Xu Yang*. 2012. Photosynthetic Toxicity and Oxidative Damage Induced by Nano-Fe3O4 on Chlorella vulgaris in Aquatic Environment, Open Journal of Ecology, 2(1): 21-28.

 

学术兼职

- 中国环境科学学会室内环境与健康分会委员

- 中国环境科学学会环境医学与健康分会委员

- 湖北省预防医学会环境卫生专业委员会委员

- 《环境与职业医学》编委