教授

  • 姓名:宋光
  • 职称:研究员
  • 研究领域:生物大分子筛选检测分析
  • 联系方式:guangsong@ccnu.edu.cn
  • 办公室地址:华中师大生科院5号楼
  • 更多信息:

教育及工作背景:

2001.9-2005.7 河南师范大学生命科学学院生物技术专业理学学士

2005.9-2012.7 中国科学院北京基因组研究所、生物化学与分子生物学专业、理学博士

2012.9-2021.4 约翰斯·霍普金斯大学医学院、药学与分子科学系、博士后/RA

2021.6- 至今 华中师范大学生命科学学院、研究员


荣誉奖励

湖北省高层次人才支持计划(创新)项目(2022年)

武汉市“武汉英寸”优秀青年人才(2021年)


主要研究领域:

1. 蛋白质芯片技术及其在筛选检测生物大分子相互作用中的应用研究

2. DNA表观遗传修饰阅读蛋白在基因表达调控中的作用机制研究

3. 基于DNA标签标记的生物大分子检测技术


招生招聘:

热忱欢迎生物化学与分子生物学、基础医学和生物技术等相关专业的同学报考加盟。

代表性论文:

1.  Song, G.*, Wang, G.*, Luo, X.*, Cheng, Y., Song, Q., Wan, J., Moore, C., Song, H., Jin, P., Qian, J., and Zhu, H. (2021) An all-to-all approach to the identification of sequence-specific readers for epigenetic DNA modifications on cytosine. Nature Communications 2021 Feb 4;12(1):795.

2. Song, G.*, Lee, E.*, Pan, J.*, Xu, M.*, Rho, H., Cheng, Y., Whitt, N., Yang, S., Kouznetsova, J., Klumpp-Thomas, C., Michael, S., Moore, C., Yoon, K., Christian, K., Simeonov, A., Huang, W., Xia, M., Huang, R., Lal-Nag, M., Tang, H., Zheng, W., Qian, J., Song, H., Ming, G., and Zhu, H. (2021) An Integrated Systems Biology Approach 1 Identifies the Proteasome as a Critical Host Machinery for ZIKV and DENV Replication. Genomics, Proteomics & Bioinformatics. Volume 19, Issue 1, February 2021, Pages 108-122

3. Wen, X.*, Song, G.*, Hu, C.*, Pan, J., Wu, Z., Li, L., Liu, C., Tian, X., Zhang, F., Qian, J., Zhu, H., and Li, Y. (2021) Identification of novel serological autoantibodies in Takayasu arteritis patients using HuProt arrays. Molecular & Cellular Proteomics. 2021; 20:100036. doi: 10.1074/mcp.RA120.002119

4. Song, G.*, Chen, L.*, Zhang, B., Song, Q., Yu, Y., Moore, C., Wang, T., Shih, I., Zhang, H., Chan, D., Zhang, Z., and Zhu, H. (2019) Proteome-wide Tyrosine Phosphorylation Analysis Reveals Dysregulated Signaling Pathways in Ovarian Tumors. Molecular & Cellular Proteomics : MCP 18, 448-460

5. Liu, L.*, Li, T.*, Song, G.*, He, Q., Yin, Y., Lu, J., Bi, X., Wang, K., Luo, S., Chen, Y., Yang, Y., Sun, B., Yang, Y., Wu, J., Zhu, H., and Shen, X. (2019) Insight into novel RNA-binding activities via large-scale analysis of lncRNA-bound proteome and IDH1-bound transcriptome. Nucleic Acids Research 47, 2244-2262

6. Song, G.*, Rho, H.*, Pan, J.*, Ramos, P., Yoon, K., Medina, F., Lee, E. M., Eichinger, D., Ming, G., Munoz-Jordan, J., Tang, H., Pino, I., Song, H., Qian, J., and Zhu, H. (2018) Multiplexed Biomarker Panels Discriminate Zika and Dengue Virus Infection in Humans. Molecular & Cellular Proteomics : MCP 17, 349-356

7. Yoon, K., Song, G., Qian, X., Pan, J., Xu, D., Rho, H., Kim, N., Habela, C., Zheng, L., Jacob, F., Zhang, F., Lee, E., Huang, W., Ringeling, F., Vissers, C., Li, C., Yuan, L., Kang, K., Kim, S., Yeo, J., Cheng, Y., Liu, S., Wen, Z., Qin, C., Wu, Q., Christian, K., Tang, H., Jin, P., Xu, Z., Qian, J., Zhu, H., Song, H., and Ming, G. (2017) Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins. Cell Stem Cell 21, 349-358 e346

8. Pan, J.*, Song, G.*, Chen, D.*, Li, Y., Liu, S., Hu, S., Rosa, C., Eichinger, D., Pino, I., Zhu, H., Qian, J., and Huang, Y. (2017) Identification of Serological Biomarkers for Early Diagnosis of Lung Cancer Using a Protein Array-Based Approach. Molecular & Cellular Proteomics: MCP 16, 2069-2078

9. Song, G., Neiswinger, J., and Zhu, H. (2016) Characterization of RNA-Binding Proteins Using Protein Microarrays. Cold Spring Harbor Protocols 2016

10. Song, G.*, Hu, C.*, Zhu, H., Wang, L., Zhang, F., Li, Y., and Wu, L. (2013) New centromere autoantigens identified in systemic sclerosis using centromere protein microarrays. The Journal of Rheumatology 40, 461-468

11. Song, G.*, Hu, C.*, Zhu, H., Li, X., Zhao, L., Zhou, R., Zhang, X., Zhang, F., Wu, L., and Li, Y. (2013) Comparative proteomics study on liver mitochondria of primary biliary cirrhosis mouse model. BMC Gastroenterology 13, 64

     12. Hu, C.*, Song, G.*, Huang, W., Liu, G., Deng, C., Zeng, H., Wang, L., Zhang, F., Zhang, X., Jeong, J., Blackshaw, S., Jiang, L., Zhu, H., Wu, L., and Li, Y. (2012) Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays. Molecular & Cellular Proteomics : MCP 11, 669-680