教育经历：

2010/03–2012/03 多伦多大学，博士联合培养

2007/09–2012/06 华中师范大学，生命科学学院，理学博士

2002/09–2006/06  鲁东大学，生命科学学院，理学学士

工作经历：

2024/07-至今 华中师范大学，生命科学学院，教授

2015/07–2024/06 华中师范大学，生命科学学院，副教授

2012/07–2015/06  华中师范大学，生命科学学院，讲师

2012/07–2014/05 多伦多大学，SGC基因组中心，博士后

荣誉或奖励：

1.2024-2026  湖北省“青年拔尖”人才计划

2.2015-2021 湖北省“楚天学子”人才计划

3.2014-2016 华中师范大学“三育人”先进个人

承担科研项目：

1.国家自然科学基金面上项目：人源PGC-1α-NRF1-TFAM途径调控线粒体生物发生的分子机制，2024/01-2027/12，主持。

2.国家自然科学基金面上项目：MIS复合物介导酵母孢子形成的分子机制研究，2018/01-2021/12，主持。

3.湖北省人才计划：转录调控相关疾病靶点的致病机制及其靶向药物研究，2024/01-2026/12，主持。

4.国家自然科学基金青年项目：WDR82介导SETD1A复合物定位于基因转录起始位点进而调控基因转录的分子机理研究，2014/01-2017/12，主持。

5.湖北省自然科学基金面上项目：生物标记物hNGAL多价高灵敏免疫检测抗体的研发，2017/01-2018/12，主持。

6.湖北省自然科学基金青年项目：WDR82识别SETD1A和RNA聚合酶Ⅱ磷酸化修饰CTD的分子机理研究，2013/01-2014/12，主持。

代表性论文：

1.Liu K*^#, Li WF^#, Xiao YQ, Lei M, Zhang M, Min JR*. Molecular mechanism of specific DNA sequence recognition by NRF1, Nucleic Acids Res, 2024, 52(2): 953-966

2.Tang RJ, Zhou MQ, Chen YW, Jiang ZH, Fan XN, Zhang JH, Dong AP, Lv L, Mao S, Chen F, Gao GJ, Min JR, Liu K*, Yuan K*. H3K14ac facilitates the reinstallation of constitutive heterochromatin in Drosophila early embryos by engaging Eggless/SetDB1, Proc Natl Acad Sci U S A (PNAS), 2024, 33, e2321859121

3.Liu K*^#, Xiao YQ^#, Gan LY, Li WF, Zhang J, Min JR*. Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors, Nucleic Acids Res, 2023, 51(15): 8270-8282

4.Yang YW^#, Liu K^# Huang D, Yu C, Chen SZ, Chen M, Qiu BS*. Functional specialization of expanded orange carotenoid protein paralogs in subaerial Nostoc species, Plant Physiol, 2023, 192(4): 2640-2655

5.Liu K*^#, Zhang J^#, Xiao YQ, Yang A, Song XS, Li YJ, Chen YX, Hughes TR, Min JR*. Structural insights into DNA recognition by the BEN domain of the transcription factor BANP, J Biol Chem, 2023, 299(6): 104734

6.Wu ZB^#, Chen SZ^#, Zhou MQ^#, Jia LB, Li ZH, Zhang XY, Min JR*, Liu K*. Family-wide Characterization of Methylated DNA Binding Ability of Arabidopsis MBDs. J Mol Biol, 2022, 434(2): 167404

7.Chen SZ^#, Zhou MQ^#, Dong AP, Loppnau P, Wang M, Min JR*, Liu K*. Structural basis of the TAM domain of BAZ2A in binding to DNA or RNA independent of methylation status. J Biol Chem, 2021, 297(6): 101351

8.Zhang J, Chen SZ, Liu K*. Structural insights into piRNA biogenesis. Biochim Biophys Acta Gene Regul Mech, 2022, 1865(2): 194799

9.Min JR*, Liu K*. Structures of chromatin modulators in complex with nucleosome. Curr Opin Chem Biol, 2021, 63: 105-114

10.Liu K*, Min JR*. Structural basis for the recognition of non-methylated DNA by the CXXC domain. J Mol Biol, 2019, 432: 1674-1686

11.Liu K^#, Lei M^#, Wu ZB, Gan B, Cheng H, Li YJ, Min JR*. Structural analyses reveal that MBD3 is a methylated CG binder. FEBS J, 2019, 286(16): 3240-3254

12.Gan B, Chen SZ, Liu H, Min JR, Liu K*. Structure and function of eTudor domain containing TDRD proteins. Crit Rev Biochem Mol Biol, 2019, 54(2): 119-132

13.Chen SZ, Zhang WL, Min JR, Liu K*. Lesson from a Fab-enabled co-crystallization study of TDRD2 and PIWIL1. Methods, 2020, 175: 72-78

14.Lei M, Tempel W, Chen SZ, Liu K*, Min JR*. Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain. Biochim Biophys Acta Gene Regul Mech, 2019, 1862(9): 194409

15.Liu K^#, Xu C^#, Lei M^#, Yang A, Loppnau P, Hughes TR, Min JR*. Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA. J Biol Chem, 2018, 293(19): 7344-7354

16.Xu C^#, Liu K^#, Lei M, Yang A, Li YJ, Hughes TR, Min JR*. DNA sequence recognition of human CXXC domains and their structural determinants. Structure, 2018, 26(1): 85-95

17.Zhang H^#, Liu K^#, Izumi N^#, Huang HM, Ding DQ, Ni ZY, Sidhu SS, Chen C, Tomari Y*, Min JR*. Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2. Proc Natl Acad Sci U S A (PNAS), 2017, 114(47): 12483-12488

18.Liu K, Liu Y, Lau JL, Min JR*. Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation. Pharmacol & Therap, 2015, 151: 121-140

19.Xu C^#, Wang X^#, Liu K^#, Roundtree IA, Tempel W, Li YJ, Lu ZK, He C*, Min JR*. Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain. Nat Chem Biol, 2014, 10(11): 927-929

20.Liu YL^#, Liu K^#, Qin S, Xu C, Min JR*. Epigenetic targets and drug discovery Part 1: histone methylation. Pharmacol & Therap, 2014, 143(3): 275-294

21.Xu C^#, Liu K^#, Tempel W, Demetriades M, Aik WS, Schofield CJ, Min JR*. Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single stranded m6A RNA demethylation. J Biol Chem, 2014, 289(25): 17299-17311

22.Liu K^#, Chen C^#, Guo YH^#, Lam R, Bian CB, Xu C, Zhao DY, Jin J, MacKenzie F, Pawson T*, Min JR*. Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain. Proc Natl Acad Sci U S A (PNAS), 2010, 107: 18398-18403