教育经历:
2011年9月- 2017年1月 北京大学,生命科学学院,理学博士。
2007年9月- 2011年6月 南京农业大学,生命科学学院,理学学士。
工作经历:
2020年9月-至今,华中师范大学,生命科学学院,教授
2017年2月- 2020年9月,华中师范大学,生命科学学院,副教授
2013年10月- 2015年10月,美国加州大学圣地亚哥分校,物理系,访问学者
荣誉或奖励:
2023年 湖北省自然科学二等奖(“细菌生长调控与环境响应机制的定量解析”,第二完成人)。
2022年 湖北省杰青
2022年 湖北省向上向善好青年
2020年 国家高层次人才支持计划(青年)项目
2017年 湖北省青年人才支持计划
2023年 周洪宇华大卓越人才奖
2020年 华中师范大学“桂子学者”
2020年 华中师范大学“三育人先进个人”
2019年 华中师范大学“桂子青年学者”
主要研究领域:
研究微生物如何对各种生态环境进行适应,进而对其自身生长进行调控。主要采用定量与合成生物学手段,揭示细菌生长与基因表达及蛋白质合成效率的偶联机制,以及细菌生长与细胞大小及细胞周期的偶联机制,以期破译微生物生长的内在限制性因素,进而从整体水平理解微生物系统的顶层设计原理。
承担科研项目:
1.国家自然科学基金面上项目,32270034,全局调控因子(p)ppGpp对需钠弧菌细胞大小与细胞周期的调控机制研究,2023.01-2026.12,54万,在研,主持。
2.湖北省杰出青年科学基金项目,2022CFA044,全局调控因子(p)ppGpp对金黄色葡萄球菌抗生素耐受性的调控机制研究,2022.10.1-2025.9.30,30万,在研,主持。
3.国家自然科学基金优秀青年科学基金项目,32022001,微生物生长生理,2021.01-2023.12,120万,结题,主持。(结题考核结果为优秀)
4.国家自然科学基金面上项目,31870028,需钠弧菌细胞大小及细胞周期与生长偶联的定量模式研究,2019.01-2022.12,59万,结题,主持。
5.国家自然科学基金青年项目,31700039,核糖核苷酸还原酶对大肠杆菌细胞大小与细胞周期的调控研究,2018.01-2020.12,25万,结题,主持。
代表性论文:
1.Zhu M*, Mu H, Dai X* (2024) Integrated control of cell growth and stress response by (p)ppGpp in Escherichia coli, a seesaw fashion. iScience. 27(2):108818.
2.Zhu M, et al. (2023). A fitness trade-off between growth and survival governed by Spo0A-mediated proteome allocation constraints in Bacillus subtilis. Science Advances, 9(39): eadg9733.
3.Zhu M*; Dai X*; (2023). Stringent response ensures the timely adaptation of bacterial growth to nutrient downshift. Nature Communications, 14: 467. (ESI高被引论文)
4.Mu H, et al., Zhu M*. (2023). Recent functional insights into the magic role of (p)ppGpp in growth control. Comput Struct Biotec, 21, 168-175.
5.Zhu M*, Mu H, Han F, Wang Q, Dai X*. (2021). Quantitative analysis of asynchronous transcription-translation and transcription processivity in Bacillus subtilis under various growth conditions. iScience. 24(11):103333.
6.Zhu M*, Mu H, Jia M, Deng L, Dai X*. (2021). Control of ribosome synthesis in bacteria: the important role of rRNA chain elongation rate. Science China Life Sciences. 64(5), 795-802.
7.Dai X*, Zhu M*. (2020). Coupling of Ribosome Synthesis and Translational Capacity with Cell Growth. Trends Biochem Sci. 45(8), 681-692.
8.Zhu M*, Dai X*. (2020). Bacterial stress defense: the crucial role of ribosome speed. Cell. Mol. Life Sci. 77(5), 853–858 (2020).
9.Zhu M, Mori M, Hwa T*, Dai X*. (2019). Disruption of transcription-translation coordination in Escherichia coli leads to premature transcriptional termination. Nature Microbiology. 4(12), 2347-2356.
10.Zhu M*, Dai X*. (2019). Maintenance of translational elongation rate underlies the survival of Escherichia coli during oxidative stress. Nucleic Acids Research. 47(14) 7592-7604, (2019).
11.Zhu M*, Pan, Y, Dai X*. (2019). (p)ppGpp: the magic governor of bacterial growth economy. Curr Genet. 65(5), 1121-1125.
12.Zhu M, Dai X*. (2019). Growth suppression by altered (p)ppGpp level results from non-optimal resource allocation in Escherichia coli. Nucleic acids Research. 47(9), 4684-4693. (recommended in faculty of 1000 by Professor KC Huang (Stanford))
13.Dai X, Shen Z, Wang Y, Zhu M*. (2018). Sinorhizobium meliloti, a slow-growing bacterium, exhibits growth rate dependence of cell size under nutrient limitation. mSphere 3:e00567-18. (Highlighted by Nature Reviews Microbiology, https://www.nature.com/articles/s41579-018-0124-y)
14.Dai X*, Zhu M*. (2018). High osmolarity modulates bacterial cell size through reducing initiation volume in Escherichia coli. mSphere 3:e00430-18.
15.Zhu M*, Dai X*. (2018). High salt cross-protects Escherichia coli from antibiotic treatment through increasing efflux pump expression. mSphere 3:e00095-18.
16.Zhu M*, Dai X*. (2018) On the intrinsic constraint of bacterial growth rate: M. tuberculosis’s view of protein translation capacity. Critical Reviews in Microbiology. 44(4), 455-464.
17.Dai X#, Zhu M#, Warren M, Balakrishnan R, Okano H, Williamson JR, Fredrick K, Hwa T. (2018). Slowdown of translational elongation in Escherichia coli under hyperosmotic stress. mBio 9:e02375-17.
18.Zhu M#, Dai X#, Guo W, Ge Z, Yang M, Wang H, Wang Y-P. (2017). Manipulating the bacterial cell cycle and cell size by titrating the expression of ribonucleotide reductase. mBio 8:e01741-17.
19.Dai X#, Zhu M#, Warren M, Balakrishnan R, Okano H, Fredrick K, Wang Y. P*, & Hwa T*. (2016). Reduction of translating ribosomes enables Escherichia coli to maintain elongation rates during slow growth. Nature Microbiology, 2, 16231.
20.Zhu M, Dai X*, & Wang Y. P*. (2016). Real time determination of bacterial in vivo translation elongation speed based on LacZ alpha complementation assay. Nucleic acids research, 44(20): e155.
21.Basan M#, Zhu M#, Dai X, Warren M, Sévin D, Wang Y. P& Hwa T*. (2015). Inflating bacterial cells by increased protein synthesis. Molecular Systems Biology, 11(10), 836.
22.Dai X#, Zhu M#, & Wang Y. P*. (2014). Circular permutation of E. coli EPSP synthase: increased inhibitor resistance, improved catalytic activity, and an indicator for protein fragment complementation. Chemical Communications, 50(15), 1830-1832.