教育及工作背景：

2005.9-2012.7 中国科学院北京基因组研究所、生物化学与分子生物学专业、理学博士

2012.9-2021.4 约翰斯·霍普金斯大学医学院、药学与分子科学系、博士后/RA

2021.6- 至今    华中师范大学生命科学学院、研究员

荣誉奖励：

湖北省高层次人才支持计划（创新）项目（2022年）

武汉市“武汉英寸”优秀青年人才（2021年）

主要研究领域：

1.生物大分子互作技术

2.慢性疾病的分子调控及与干预机制研究

   聚焦代谢相关活性分子在疾病中的分子调控机制，旨在揭示肿瘤治疗响应和血管稳态调控的基本规律。我们利用肿瘤细胞和血管内皮模型，系统研究短链脂肪酸等代谢活性分子在调控细胞命运、表观遗传重塑及功能稳态方面的作用。通过结合转录组学、蛋白质组学、表观遗传学和细胞功能实验，实验室探索代谢干预对肿瘤敏感性增强及高糖相关血管损伤修复的机制。

发表论文：

1. Qu S.*, Li K., Lili Fan L, Miao C., Wang W., Wang X., Song G.^# Epigenetic activation of CHST2 by promoter hypomethylation promotes progression of triple-negative breast cancer, bioRxiv  2026.02.12.705678

2. Fan L., Qu S., Miao C., Wu D., Rao Y., Xu W., He Y., Song G,^#.Panax notoginseng saponins protect the blood–brain barrier against oxidative stress by activating the Akap12–PI3K/AKT–AQP1 signaling axis, International Journal of Biological Macromolecules, 2026 February 2026.

3. Zhao Y. *, Han Y., Zhang H.#, Hu B., Qu S., Miao C., Qin L., Song G^#. The investigation of the photocatalytic degradation and bio-antimicrobial properties based on the biomass carbon dots and the composite nanofiber membranes of biomass carbon dots and PLA. Diamond and Related Materials. 2025 July 4: 112612

4. Ahmadi AR*, Song G*, Gao T*, Ma J, Han X, Hu MW, Cameron AM, Wesson RN, Philosophe B, Ottmann S, King E, Gurakar A, Qi L, Peiffer B, Burdick J, Anders R, Zhou Z, Lu H, Feng D, Chen CS, Qian J, Gao B, Zhu H, Sun Z. Discovery and characterization of cross-reactive intrahepatic antibodies in severe alcoholic hepatitis. Elife. 2023 Dec 6;12:RP86678.

5. Liu C*, Song G*, Yan S, He Y, Hu C, Hou Y, Wen X, Li L, Zhang F, Zhu H, Li Y. Identification of Anti-SNRPA as a Novel Serological Biomarker for Systemic Sclerosis Diagnosis. J Proteome Res. 2023 Oct 6;22(10):3254-3263.

6. Song, G.*, Wang, G.*, Luo, X.*, Cheng, Y., Song, Q., Wan, J., Moore, C., Song, H., Jin, P., Qian, J., and Zhu, H. An all-to-all approach to the identification of sequence-specific readers for epigenetic DNA modifications on cytosine. Nature Communications 2021 Feb 4;12(1):795.

7. Song, G.*, Lee, E.*, Pan, J.*, Xu, M.*, Rho, H., Cheng, Y., Whitt, N., Yang, S., Kouznetsova, J., Klumpp-Thomas, C., Michael, S., Moore, C., Yoon, K., Christian, K., Simeonov, A., Huang, W., Xia, M., Huang, R., Lal-Nag, M., Tang, H., Zheng, W., Qian, J., Song, H., Ming, G., and Zhu, H. An Integrated Systems Biology Approach 1 Identifies the Proteasome as a Critical Host Machinery for ZIKV and DENV Replication. Genomics, Proteomics & Bioinformatics. 2021 Feb;19(1):108-122.

8. Wen, X.*, Song, G.*, Hu, C.*, Pan, J., Wu, Z., Li, L., Liu, C., Tian, X., Zhang, F., Qian, J., Zhu, H., and Li, Y. Identification of novel serological autoantibodies in Takayasu arteritis patients using HuProt arrays. Molecular & Cellular Proteomics. 2021;20:100036.

9. Song, G.*, Chen, L.*, Zhang, B., Song, Q., Yu, Y., Moore, C., Wang, T., Shih, I., Zhang, H., Chan, D., Zhang, Z., and Zhu, H. Proteome-wide Tyrosine Phosphorylation Analysis Reveals Dysregulated Signaling Pathways in Ovarian Tumors. Molecular & Cellular Proteomics. 2019 Mar;18(3):448-460.

10. Liu, L.*, Li, T.*, Song, G.*, He, Q., Yin, Y., Lu, J., Bi, X., Wang, K., Luo, S., Chen, Y., Yang, Y., Sun, B., Yang, Y., Wu, J., Zhu, H., and Shen, X. Insight into novel RNA-binding activities via large-scale analysis of lncRNA-bound proteome and IDH1-bound transcriptome. Nucleic Acids Research. 2019 Mar 18;47(5):2244-2262.

11. Zhai, R., Wang, Y., Qi, L., Williams, G., Gao, B., Song, G., Burdick, J., and Sun, Z. Pharmacological Mobilization of Endogenous Bone Marrow Stem Cells Promotes Liver Regeneration after Extensive Liver Resection in Rats. Scientific Reports. 2018 Feb 26;8(1):3587.

12. Yang, S., Xu, M., Lee, E., Gorshkov, K., Shiryaev, S., He, S., Sun, W., Cheng, Y., Hu, X., Tharappel, A., Lu, B., Pinto, A., Farhy, C., Huang, C., Zhang, Z., Zhu, W., Wu, Y., Zhou, Y., Song, G., Zhu, H., Shamim, K., Martinez-Romero, C., Garcia-Sastre, A., Preston, R., Jayaweera, D., Huang, R., Huang, W., Xia, M., Simeonov, A., Ming, G., Qiu, X., Terskikh, A., Tang, H., Song, H., and Zheng, W. Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry. Cell Discovery. 2018 Jun 5;4:31.

13. Venkataraman, A., Yang, K., Irizarry, J., Mackiewicz, M., Mita, P., Kuang, Z., Xue, L., Ghosh, D., Liu, S., Ramos, P., Hu, S., Bayron Kain, D., Keegan, S., Saul, R., Colantonio, S., Zhang, H., Behn, F., Song, G., Albino, E., Asencio, L., Ramos, L., Lugo, L., Morell, G., Rivera, J., Ruiz, K., Almodovar, R., Nazario, L., Murphy, K., Vargas, I., Rivera-Pacheco, Z., Rosa, C., Vargas, M., McDade, J., Clark, B., Yoo, S., Khambadkone, S., de Melo, J., Stevanovic, M., Jiang, L., Li, Y., Yap, W., Jones, B., Tandon, A., Campbell, E., Montelione, G., Anderson, S., Myers, R., Boeke, J., Fenyo, D., Whiteley, G., Bader, J., Pino, I., Eichinger, D., Zhu, H., and Blackshaw, S. A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nature Methods. 2018 May;15(5):330-338.

14. Song, G.*, Rho, H.*, Pan, J.*, Ramos, P., Yoon, K., Medina, F., Lee, E. M., Eichinger, D., Ming, G., Munoz-Jordan, J., Tang, H., Pino, I., Song, H., Qian, J., and Zhu, H. Multiplexed Biomarker Panels Discriminate Zika and Dengue Virus Infection in Humans. Molecular & Cellular Proteomics. 2018 Feb;17(2):349-356.

15. Yoon, K., Song, G., Qian, X., Pan, J., Xu, D., Rho, H., Kim, N., Habela, C., Zheng, L., Jacob, F., Zhang, F., Lee, E., Huang, W., Ringeling, F., Vissers, C., Li, C., Yuan, L., Kang, K., Kim, S., Yeo, J., Cheng, Y., Liu, S., Wen, Z., Qin, C., Wu, Q., Christian, K., Tang, H., Jin, P., Xu, Z., Qian, J., Zhu, H., Song, H., and Ming, G. Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins. Cell Stem Cell. 2017 Sep 7;21(3):349-358.e6.

16. Pan, J.*, Song, G.*, Chen, D.*, Li, Y., Liu, S., Hu, S., Rosa, C., Eichinger, D., Pino, I., Zhu, H., Qian, J., and Huang, Y. Identification of Serological Biomarkers for Early Diagnosis of Lung Cancer Using a Protein Array-Based Approach. Molecular & Cellular Proteomics. 2017 Dec;16(12):2069-2078.

17. Hu, C., Pan, J., Song, G., Wen, X., Wu, Z., Chen, S., Mo, W., Zhang, F., Qian, J., Zhu, H., and Li, Y. Identification of Novel Biomarkers for Behcet Disease Diagnosis Using Human Proteome Microarray Approach. Molecular & cellular proteomics. 2017 Feb;16(2):147-156.

18. Song, G., Neiswinger, J., and Zhu, H. Characterization of RNA-Binding Proteins Using Protein Microarrays. Cold Spring Harbor Protocols. 2016 Oct 3;2016(10).

19. Pham, X., Song, G., Lao, S., Goff, L., Zhu, H., Valle, D., and Avramopoulos, D. The DPYSL2 gene connects mTOR and schizophrenia. Translational psychiatry. 2016 Nov 1;6(11):e933.

20. Neiswinger, J., Uzoma, I., Cox, E., Rho, H., Song, G., Paul, C., Jeong, J., Lu, K., Chen, C., and Zhu, H. Protein Microarrays: Flexible Tools for Scientific Innovation. Cold Spring Harbor Protocols. 2016 Oct 3;2016(10).

21. Yin, Y., Yan, P., Lu, J., Song, G., Zhu, Y., Li, Z., Zhao, Y., Shen, B., Huang, X., Zhu, H., Orkin, S., and Shen, X. Opposing Roles for the lncRNA Haunt and Its Genomic Locus in Regulating HOXA Gene Activation during Embryonic Stem Cell Differentiation. Cell Stem Cell. 2015 May 7;16(5):504-16.

22. Hu, C., Huang, W., Chen, H., Song, G., Li, P., Shan, Q., Zhang, X., Zhang, F., Zhu, H., Wu, L., and Li, Y. Autoantibody profiling on human proteome microarray for biomarker discovery in cerebrospinal fluid and sera of neuropsychiatric lupus. PLoS One.  2015 May 8;10(5):e0126643.

23. Song, G.*, Hu, C.*, Zhu, H., Wang, L., Zhang, F., Li, Y., and Wu, L. New centromere autoantigens identified in systemic sclerosis using centromere protein microarrays. The Journal of Rheumatology. 2013 Apr;40(4):461-8.

24. Song, G.*, Hu, C.*, Zhu, H., Li, X., Zhao, L., Zhou, R., Zhang, X., Zhang, F., Wu, L., and Li, Y. Comparative proteomics study on liver mitochondria of primary biliary cirrhosis mouse model. BMC Gastroenterology. 2013 Apr 12;13:64.

25. Wu, L., and Song, G. Identification of new autoimmune hepatitis-specific autoantigens by using protein microarray technology. Methods in Molecular Biology. 2012;909:227-39.

26. Hu, C.*, Song, G.*, Huang, W., Liu, G., Deng, C., Zeng, H., Wang, L., Zhang, F., Zhang, X., Jeong, J., Blackshaw, S., Jiang, L., Zhu, H., Wu, L., and Li, Y. Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays. Molecular & Cellular Proteomics. 2012 Sep;11(9):669-80.

27. Hu, C.*, Deng, C.*, Song, G.*, Zhang, W., Zhang, S., Li, X., Li, P., Zhang, F., and Li, Y. (2011) Prevalence of autoimmune liver disease related autoantibodies in Chinese patients with primary biliary cirrhosis. Digestive Diseases and Sciences. 2011 Nov;56(11):3357-63.