教育经历:

2010.09 – 2014.06  上海交通大学，生物科学（交大理科班）专业，理学学士学位

2014.09 – 2021.06  中国科学院大学上海生化与细胞所（现分子细胞科学卓越创新中心），生物化学与分子生物学专业，理学博士学位

工作经历:

2021.07-2023.07  中国科学院，分子细胞科学卓越创新中心，博士后

2023.09-至今 华中师范大学，生命科学学院，副研究员

荣誉或奖励：

上海市“超级博士后”， 赛诺菲优秀在站博士后，中科院特别研究助理

承担科研项目：

博士后创新人才支持计划 主持

中国博士后科学基金面上资助 主持

代表性论文:

[1] C. Xu#, Y. Wang#, C. Liu#, C. Zhang#, W. Han#, X. Hong, Y. Wang, Q. Hong, S. Wang, Q. Zhao, Y. Wang, Y. Yang, K. Chen, W. Zheng, L. Kong, F. Wang, Q. Zuo, Z. Huang* and Y. Cong* (2021). "Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM." Science Advances 7(1). (此篇已被引用300余次)

[2] Y. Wang#, C. Xu#, Y. Wang#, Q. Hong#, C. Zhang#, Z. Li, S. Xu, Q. Zuo, C. Liu, Z. Huang* & Y. Cong* (2021). Conformational dynamics of the Beta and Kappa SARS-CoV-2 spike proteins and their complexes with ACE2 receptor revealed by cryo-EM. Nature communications, 12(1), 1-13.

[3] C. Zhang#, C. Xu#, W. Dai#, Y. Wang, Z. Liu, X. Zhang, X. Wang, S. Gong*, Y. Cong* and Z. Huang* (2021). " Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections." Nature Communications 12, 2904

[4] J. Chen#, Y. Wang#, C. Xu#, K. Chen, Q. Zhao, S. Wang, Y. Yin, C. Peng*, Z. Ding* and Y. Cong* (2021). "Cryo-EM of mammalian PA28αβ-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28αβ." Nature Communications 12(1): 739.

[5] C. Xu, W. Han and Y. Cong*. (2023) “Cryo-EM and cryo-ET of the spike, virion and antibody neutralization of SARS-CoV-2 and VOCs.” Current Opinion in Structural Biology 82:102664.

[6] X, Meng#, C. Xu#, J. Li#, B. Qiu#, J. Luo#, Q. Hong, Y. Tong, C. Fang, Y. Feng, R. Ma, X. Shi, C. Lin, C. Pan, X. Zhu, X. Yan, and Y. Cong. (2024). Multi-scale structures of the mammalian radial spoke and divergence of axonemal complexes in ependymal cilia. Nature Communications 15: 362.

[7] Z. Ding, C. Xu, I. Sahu, Y. Wang, Z. Fu, M. Huang, C. C. L. Wong, M. H. Glickman and Y. Cong* (2019). "Structural Snapshots of 26S Proteasome Reveal Tetraubiquitin-Induced Conformations." Molecular Cell 73(6): 1150-1161 e1156.

[8] Z. Ding, Z. Fu, C. Xu, Y. Wang, Y. Wang, J. Li, L. Kong, J. Chen, N. Li, R. Zhang and Y. Cong* (2017). "High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx." Cell Research 27(3): 373-385.

[9] Q. Hong#, W. Han#, J. Li#, S. Xu#, Y. Wang#, C. Xu, Z. Li, Y. Wang* & Y. Cong*. (2022). Molecular basis of receptor binding and antibody neutralization of Omicron. Nature, 604(7906), 546-552.

[10] Sahu, I., Mali, S. M., Sulkshane, P., C. Xu, Rozenberg, A., Morag, R., ... & Glickman, M. H*. (2021). The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag. Nature communications, 12(1), 6173.

[11] C, Zhang#, C. Liu#, J. Shi#, Y. Wang, C. Xu, X. Ye, ... & Huang, Z*. (2022). Molecular mechanism of antibody neutralization of coxsackievirus A16. Nature Communications, 13(1), 7854.

[12] W. Zheng#, F. Li#, Z. Y. Ding, H. Liu, L. Zhu, C. Xu, J. W. Li, Q. Gao, Y. X. Wang, Z. L. Fu, C. Peng, X. M. Yan*, X. L. Zhu* and Y. Cong* (2021). "Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM." Proceedings of the National Academy of Sciences of the United States of America 118(4).

[13] C. Liu, M. Jin, S. Wang, W. Han, Q. Zhao, Y. Wang, C. Xu, ... & Cong, Y. (2023)“Pathway and mechanism of tubulin folding mediated by TRiC/CCT conjugated with its ATPase cycle revealed by cryo-EM.” Communications Biology 16;6(1):531..

[14] C. Fan#, X. Ye#, Z. Ku, L. Kong, Q. Liu, C. Xu, Y. Cong* and Z. Huang* (2017). "Beta-Propiolactone Inactivation of Coxsackievirus A16 Induces Structural Alteration and Surface Modification of Viral Capsids." Journal of Virology 91(8).

[15] C, Zhang.#, Y. Wang#, Y. Zhu#, C. Liu#, C. Gu#, S. Xu#, Y. Wang, Y. Zhou, Y. Wang, W. Han, X. Hong, Y. Yang, X. Zhang, T. Wang, C. Xu, Q. Hong, S. Wang, Q. Zhao, W. Qiao, J. Zang, L. Kong, F. Wang, H. Wang, D. Qu, D. Lavillette, H. Tang, Q. Deng, Y. Xie, Y. Cong and Z. Huang (2021). "Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections." Nature Communications 12(1): 264.