教育经历:
2010.9-2014.7 哈尔滨师范大学 制药工程学士
2014.9-2019.7 中国科学技术大学(长春应化所) 物理化学 博士
工作经历:
2019.9-2024.8 武汉大学高等研究院 博士后
2024.9-至今 华中示范大学生命科学学院 副研究员
团队与招募信息:
课题组团队拥有化学、生物和生物信息学等跨学科背景,专注于脂质异构体解析与代谢机制研究。长期招收博士后、硕士研究生、申请考核制博士研究生及优秀本科生,致力于培养质谱零基础学生成为交叉科学领域的青年专家。
欢迎对质谱技术及其在脂质组学和生命科学中的应用研究感兴趣的同学加入,共同探索科学前沿!
承担科研项目:
1.湖北省自然科学基金一般面上项目(2025.01-2026.12):甘蓝型油菜种子氧化脂质分子异构化与种子老化关系的研究;
2.国家自然科学基金青年项目(2021.01-2023.12,22004092):基于可见光环加成反应的脂质双键异构分析新方法开发及其在脑缺血损伤恢复研究中的应用探索;
3.中国博士后科学基金会面上项目(2020.07-2022.07,020M672403):基于质谱的脂质异构体分析新方法的开发与应用研究。
代表性论文:
1.Feng, G.; Gao, M.; Wang, L.; Chen, J.; Hou, M.; Wan, Q.; Lin, Y.; Xu, G.; Qi, X.; Chen, S.*, Dual-resolving of positional and geometric isomers of C=C bonds via bifunctional photocycloaddition-photoisomerization reaction system. Nature Communications 2022, 13 (1), 2652.
2.Feng, G.; Hao, Y.; Wu, L.; Chen, S.*, A visible-light activated 2+2 cycloaddition reaction enables pinpointing carbon-carbon double bonds in lipids. Chemical Science 2020, 11 (27), 7244-7251.
3.Feng, G.; Gao, M.; Chen, H.; Zhang, Z.; Chen, J.; Tong, Y.; Wu, P.; Fu, R.; Lin, Y.; Chen, S.*, Stable-Isotope N-Me aziridination enables accurate quantitative C=C isomeric lipidomics. Analytical Chemistry 2024, 96 (6), 2524-2533.
4.Hao, Y.#; Zhang, Z.#; Feng, G.#; Chen, M.#; Wan, Q.; Lin, J.; Wu, L.; Nie, W.; Chen, S.*, Distinct lipid metabolic dysregulation in asymptomatic COVID-19. iScience 2021, 24 (9), 102974-102974.
5.Feng, G.; Sun, Y.; Liu, S.; Song, F.; Pi, Z.; Liu, Z.*, Stepwise targeted matching strategy from in vitro to in vivo based on ultra-high performance liquid chromatography tandem mass spectrometry technology to quickly identify and screen pharmacodynamic constituents. Talanta 2019, 194, 619-626.
6.Feng, G.; Liu, S.; Pi, Z.; Song, F.; Liu, Z.*, Comprehensive characterization of in vivo metabolic profile of Polygalae radix based on ultra-high-performance liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 2019, 165, 173-181.
7.Feng, G.; Liu, Z.; Liu, S.*; Xing, J.; Song, F.; Pi, Z., A target integration strategy for analyzing multidimensional chemical and metabolic substance groups of Ding-Zhi-Xiao-Wan prescription by using ultra-high performance liquid chromatography tandem mass spectrometry. Journal of Chromatography. A 2019, 1608, 460412-460412.
8.Feng, G.; Liu, S.; Pi, Z.; Song, F.; Liu, Z.*, Studies on the chemical and intestinal metabolic profiles of Polygalae Radix by using UHPLC-IT-MSn and UHPLC-Q-TOF-MS method coupled with intestinal bacteria incubation model in vitro. Journal of Pharmaceutical and Biomedical Analysis 2018, 148, 298-306.
9.Feng, G.; Li, S.; Liu, S.; Song, F.; Pi, Z.; Liu, Z.*, Targeted screening approach to systematically identify the absorbed effect substances of Poria Cocos in vivo using ultrahigh performance liquid chromatography tandem mass spectrometry. Journal of Agricultural and Food Chemistry 2018, 66 (31), 8319-8327.
10.Feng, G.; Zheng, Y.; Sun, Y.; Liu, S.; Pi, Z.; Song, F.; Liu, Z.*, A targeted strategy for analyzing untargeted mass spectral data to identify lanostane-type triterpene acids in Poria Cocos by integrating a scientific information system and liquid chromatography-tandem mass spectrometry combined with ion mobility spectrometry. Analytica Chimica Acta 2018, 1033, 87-99.
11.冯桂芳; 刘舒; 皮子凤; 宋凤瑞; 刘志强*, 基于超高效液相色谱-质谱联用技术的人参皂苷体外Ⅰ相代谢研究. 质谱学报 2017, 38 (04), 450-459.
12.陈素明,冯桂芳. 一种碳碳双键异构体的双键位置鉴定方法: 201911412168.2 [P]. 2020. 04. 24.
13.陈素明,冯桂芳. 同时鉴定碳碳双键异构体的双键位置和顺反异构的方法: 202111268326.2 [P]. 2022. 08. 29.