教育经历:
1993.03–1995.08 中国科学院物理研究所，博士学位
1990.09–1993.03 武汉理工大学/中国科学院物理研究所，硕士学位
1986.09–1990.06 武汉理工大学，学士学位
工作经历:
2022.12 - 至今 华中师范大学，生命科学学院，教授
2006.01 - 2022.11 华中师范大学，生命科学学院，讲座教授
2005.06 - 2022.11 多伦多大学医学院结构基因组中心，课题组长
2007.07 - 2022.11 多伦多大学医学院生理学系助理教授、副教授、教授
2015.01 - 2019.12 日本东京农工大学，GIR客座教授
2000.03 - 2005.06 美国冷泉港实验室，博士后
1999.03 - 2000.03 欧洲癌症研究所，博士后
1997.08 - 1998.12 德国埃森大学，洪堡学者
1996.06 - 1997.08 美国佛罗里达州立大学，博士后
1995.12 - 1996.06 德国萨尔兰大学，博士后
代表性论文: (*: 通讯作者)
Zhang J, Li Z, Ye L, Hou Y, Liu K*, Min J*. Structural basis of assembly-dependent activation of the MAD3-MAD4 nuclease in the Pseudomonas aeruginosa MADS defense system. Nucleic Acids Res. 2026 Oct 13;54(19):gkag1001.
Huang Y*, Liu S, Tian L, Tang Y, Dou Y, Wang H, Zheng T, Wang M, Li R, Wang Z, Zhou Z, Chen X*, Min J*. Covalent allosteric inhibition of AARS1 lactyltransferase. Nat Commun. 2026 Aug 17;17(1):9864.
Huang Y, Li Y, Chen X, Wang H, Wang Q, Liu S, Li Y, Chen Z, Ma J, Huang Z, Wan J, Ren Y*, Min J*. Fragment-Based Screening of NSD2-PWWP1 Identifies Novel Covalent Allosteric Ligands That Diminish Methyllysine and DNA Binding Abilities of NSD2. J Med Chem. 2025 Dec 11;68(23):24953-24967.
Zhang M, Chen M, Li P, Min J*. Therapeutic targeting of WDR5-MLL1 by EMBOW-derived peptides suppresses leukemia progression. Cell Chem Biol. 2025 Nov 20;32(11):1353-1366.e6.
Tang R, Zhou M, Chen Y, Jiang Z, Fan X, Zhang J, Dong A, Lv L, Mao S, Chen F, Gao G, Min J, Liu K*, Yuan K*. H3K14ac facilitates the reinstallation of constitutive heterochromatin in Drosophila early embryos by engaging Eggless/SetDB1. Proc Natl Acad Sci USA. 2024 Aug 13;121(33):e2321859121.
Huang Y, Li Y, Min J*. Advances in inhibitor development targeting the PWWP domain. Trends Pharmacol Sci. 2024 Mar;45(3):193-196.
Liu K*, Li W, Xiao Y, Lei M, Zhang M, Min J*. Molecular mechanism of specific DNA sequence recognition by NRF1. Nucleic Acids Res. 2024 Jan 25;52(2):953-966.
Liu K*, Xiao Y, Gan L, Li W, Zhang J, Min J*. Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors. Nucleic Acids Res. 2023 Aug 25;51(15):8270-8282.
Liu Y*, Iqbal A, Li W, Zuyao Ni, Wang Y, Ramprasad J, Abraham KJ, Zhang M, Zhao DY, et al, Min J*. A small molecule antagonist for the Tudor domain of SMN disrupts the interaction between SMN and RNAP II. Nat Commun. 2022 Sep 16;13(1):5453.
Yan X, Wang X, Li Y, Zhou M, Li Y, Song L, Mi W*, Min J* and Dong C*. Molecular basis for ubiquitin ligase CRL2FEM1C mediated recognition of C-degron. Nat Chem Biol. 2021, 17:263-271
Dong C, Nakagawa R, Oyama K, Yamamoto Y, Zhang W, Dong A, Li Y, Yoshimura Y, Kamiya H, Nakayama JI, Ueda J, Min J*. Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19. Elife. 2020, 9:e58675
Dong C, Liu Y, Lyu TJ, Beldar S, Lamb KN, Tempel W, Li Y, Li Z, James LI, Qin S*, Wang Y*, Min J*. Structural Basis for the Binding Selectivity of Human CDY Chromodomains. Cell Chem Biol. 2020, 27:827-838
Dong C, Chen SJ, Melnykov A, Weirich S, Sun K, Jeltsch A, Varshavsky A*, Min J*. Recognition of nonproline N-terminal residues by the Pro/N-degron pathway. Proc Natl Acad Sci USA. 2020, 117:14158-14167
Zhang H, Devoucoux M, Song X, Li L, Ayaz G, Cheng H, Tempel W, Dong C, Loppnau P, Côté J*, Min J*. Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex. Cell Rep. 2020, 30:3996-4002.e4
Liu Y, Qin S, Chen TY, Lei M, Dhar SS, Ho JC, Dong A, Loppnau P, Li Y, Lee MG* and Min J*, Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4. Nat Commun. 2019, 10:36
Dong C, Zhang H, Li L, Tempel W, Loppnau P, Min J*. Molecular basis of GID4-mediated recognition of Pro/N-degrons for the Pro/N-end rule pathway. Nat Chem Biol. 2018, 14:466-473
Zhang H, Zhou B, Qin S, Xu J, Harding R, Tempel W, Nayak V, Li Y, Loppnau P, Dou Y, Min J*. Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis. Genes Dev. 2018, 32:341-346
Jurkowska R, Qin S, Kungulovski G, Tempel W, Liu Y, Bashtrykov P, Stiefelmaier J, Jurkowski T, Kudithipudi S, Tamas R, Wu H, Dombrovski L, Loppnau P, Reinhardt R, Min J*, Jeltsch A*. H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1. Nat Commun. 2017, 8:2057
Zhang H, Liu K, Izumi N, Huang H, Ding D, Ni Z, Sidhu S, Chen C, Tomari Y*, and Min J*. Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2. Proc Natl Acad Sci USA. 2017, 114:12483-12488
Xu C, Ishikawa H, Izumikawa K, Li L, He H, Nobe Y, Yamauchi Y, Shahjee HM, Wu XH, Yu YT, Isobe T, Takahashi N, Min J*. Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly. Genes Dev. 2016, 30:2376-2390
Liu Y, Li L, Min J*. HDAC6 finally crystal clear. Nat Chem Biol. 2016, 12:660-661
Dong C, Mao Y, Tempel W, Qin S, Li L, Loppnau P, Huang R, Min J*. Structural basis for substrate recognition by the human N-terminal methyltransferase 1. Genes Dev. 2015 Nov; 29(22):2343-8.
Xu C*, Wang X, Liu K, Roundtree IA, Tempel W, Li Y, Lu Z, He C*, Min J*. Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain. Nat Chem Biol. 2014, 10:927-9
Ni Z, Xu C, Guo X, Hunter GO, Kuznetsova OV, Tempel W, Marcon E, Zhong G, Guo H, Kuo WH, Li J, Young P, Olsen JB, Wan C, Loppnau P, El Bakkouri M, Senisterra GA, He H, Huang H, Sidhu SS, Emili A, Murphy S, Mosley AL, Arrowsmith CH, Min J*, Greenblatt JF*. RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation. Nat Struct Mol Biol. 2014 Aug; 21(8):686-695.